Antioxidant BHT 264
CAS:128-37-0
Purity:99%
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Product Details
Only one FDA-approved β-lactamase inhibi...
Hydrates are common in pharmaceutical de...
An efficient synthesis of avibactam star...
The invention discloses an effective sta...
The invention discloses a synthesis meth...
The invention belongs to the technical f...
The invention relates to medical compoun...
![(2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide](/upload/2026/7/64134412-dd10-450a-b85a-697f298978e7.png)
(2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
![(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt](/upload/2026/7/59e82c31-5577-4848-bd12-8fcbaff1ab34.png)
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
| Conditions | Yield |
|---|---|
|
(2S,5R)-6-hydroxy-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide;
With
pyridine; sulfur trioxide pyridine complex;
at 20 ℃;
for 20h;
With
sodium dihydrogenphosphate;
In
water;
|
80% |
|
Multi-step reaction with 2 steps
1.1: α-picoline; thiocyanate trioxide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
2.1: 2,2,2-trifluoroethanol; tetrafluoroboric acid
2.2: 1 h / 0 °C
With
α-picoline; tetrafluoroboric acid; thiocyanate trioxide; 2,2,2-trifluoroethanol;
In
tetrahydrofuran;
|
|
|
Multi-step reaction with 2 steps
1: triethylamine; sulfur trioxide trimethylamine complex / ethanol; water
2: sodium 2-ethylhexanoic acid / ethanol
With
sulfur trioxide trimethylamine complex; triethylamine; sodium 2-ethylhexanoic acid;
In
ethanol; water;
|
|
|
Multi-step reaction with 2 steps
1: triethylamine; sulfur trioxide trimethylamine complex / ethanol; water
2: sodium 2-ethylhexanoic acid / ethanol
With
sulfur trioxide trimethylamine complex; triethylamine; sodium 2-ethylhexanoic acid;
In
ethanol; water;
|
|
|
Multi-step reaction with 3 steps
1.1: sodium hexamethyldisilazane; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / acetonitrile / 1.33 h / 20 °C / Inert atmosphere
3.1: sodium hydrogencarbonate / dimethylsulfoxide-d6; water-d2
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; palladium 10% on activated carbon; hydrogen; sodium hexamethyldisilazane; sodium hydrogencarbonate;
In
tetrahydrofuran; dimethylsulfoxide-d6; water-d2; acetonitrile;
|
![(1R,2S,5R)-7-oxo-6-sulfonyloxy-1,6-diazabicyclo[3,2,1]octane-2-carboxamide tributylbenzylammonium](/upload/2026/7/37182267-a6cf-47d3-9128-ea1fc6bbc0ef.png)
(1R,2S,5R)-7-oxo-6-sulfonyloxy-1,6-diazabicyclo[3,2,1]octane-2-carboxamide tributylbenzylammonium
(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt
| Conditions | Yield |
|---|---|
|
With
sodium 2-ethylhexanoic acid;
In
ethanol; water;
at 15 - 40 ℃;
for 4h;
|
80% |
|
With
sodium 2-ethylhexanoic acid;
In
ethanol;
|
4.6 g |
|
With
sodium isooctanoate;
In
ethanol; water;
at 35 - 40 ℃;
for 4h;
|
(1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide
(2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid amide
(2S,5R)-5-benzyloxyaminopiperidin-2-carboxylic acid benzyl ester oxalic acid salt
ethyl (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxylate oxalic acid salt
({[(2S,5R)-2-carbamoyl-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3,2,1]-oct-6-yl]oxy}sulfonyl)tetrabutylammonium salt
