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Ganaxolone Good Supplier In Bulk Supply High Purity 38398-32-2 We supply high quality GANAXOLONE (CAS 38398-32-2), in stock, factory directly supply to clients, lower prices, more competitiveness.
GANAXOLONE is , while it's Molecular Formula is C22H36 O2. Ganaxolone, is synthetic neuroactive steroid, which possess sedative, anxiolytic, and anticonvulsant properties. It is also a potent and selective positive allosteric modulator of GABAA receptors. It is also shown to be used for the treatment of epilepsy.
The CAS number of GANAXOLONE is 38398-32-2.
More information of GANAXOLONE 38398-32-2 are:
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Synonyms |
3a-Hydroxy-3b-methyl-5a-pregnan-20-one; 5a-Pregnan-20-one, 3a-hydroxy-3-methyl-; CCD 1042;Ganaxolone |
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CAS Number |
38398-32-2 |
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Molecular Formula |
C22H36 O2 |
|
Molecular Weight |
332.52 |
|
Density |
1.036g/cm3 |
|
Melting Point |
190-192° |
|
Boiling Point |
434.8°Cat760mmHg |
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Flash Point |
185.4°C |
|
PSA |
37.30000 |
|
LogP |
4.98530 |
|
Pka |
15.18±0.70(Predicted) |
Ganaxolone is a 3β-methylated synthetic analog of the neurosteroid allopregnanolone that allosterically enhances GABAA receptor current. At nanomolar concentrations, it can potentiate GABA-evoked currents at GABAA receptor complexes containing α1, α2, α3, β2, and γ2L subunits expressed in Xenopus oocytes. Ganaxolone has been shown to have a broad range of antiseizure activity in animal epilepsy models and human clinical trials.
InChI:InChI=1/C22H36O2/c1-14(23)17-7-8-18-16-6-5-15-13-20(2,24)11-12-21(15,3)19(16)9-10-22(17,18)4/h15-19,24H,5-13H2,1-4H3/t15-,16-,17+,18-,19-,20+,21-,22+/m0/s1
Articles related to GANAXOLONE:
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Article |
Source |
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NEUROSTEROID COMPOUNDS AND METHODS FOR THEIR PREPARATION AND USE IN TREATING CENTRAL NERVOUS SYSTEM DISORDERS |
- Paragraph 0103; 0105; 0109, (2019/11/12) |
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COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS |
- Page/Page column 135, (2016/05/24) |
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