Antioxidant BHT 264
CAS:128-37-0
Purity:99%
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Pefloxacin derivative as antibacterial. Fluorinated quinolone antibacterial.
N-(5-phenyl-2-oxo-1,3-dioxol-4-yl)methyl NFLX
carbon dioxide
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
1-Phenylpropane-1,2-dione
| Conditions | Yield |
|---|---|
|
In
potassium hydroxide;
for 0.166667h;
Ambient temperature;
hydrolyses (in AGJ :half-life >20 h; in AIJ :half-life >20 h); taken for complete hydrolysis in 40 percent mouse blood : 150 min;;
|
N-<(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl>norfloxacin
carbon dioxide
1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinoline carboxylic acid
dimethylglyoxal
| Conditions | Yield |
|---|---|
|
In
potassium hydroxide;
for 0.166667h;
Ambient temperature;
hydrolyses (in AGJ :half-life 12 h; in AIJ :half-life 8.5 h); taken for complete hydrolysis in 40 percent mouse blood : 15 min;;
|
The CAS number of Norfloxacin is 70458-96-7.
More information of Norfloxacin 70458-96-7 are:
|
CAS Number |
70458-96-7 |
|
Density |
1.344 g/cm3 |
|
Melting Point |
220 °C |
|
Boiling Point |
555.8 °C at 760 mmHg |
|
Flash Point |
289.9 °C |
|
Vapor Pressure |
2.6E-20mmHg at 25°C |
|
HS CODE |
29335990 |
|
PSA |
74.57000 |
|
LogP |
1.66210 |
|
Pka |
pKa1 6.34; pKa2 8.75(at 25℃) |
Synonyms for Norfloxacin 70458-96-7:1-Ethyl-6-fluoro-1,4-dihydro-7-(1-piperazinyl)-4-oxo-3-quinolinecarboxylicacid;AM 715;Amicrobin;Baccidal;Barazan;Barotham;Chibroxin;Chibroxine;Esclebin;Floxacin;Floxacin 400;Fulgram;Gonorcin;Lexinor;Mk 0366;N-Demethylpefloxacin;N-Desmethylpefloxacin;Neofloxacin;Neofloxin;Noflo;Nofocin;Nolicin;Noracin;Noraxin;Norbid;Norflox 400;
The chemical formula of Norfloxacin is C16H18FN3O3 which containing 16 Carbon atoms,18 Hydrogen atoms,1 Fluorine atoms,3 Nitrogen atoms and 3 Oxygen atoms,and the molecular weight of Norfloxacin is 319.336.
Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively). It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively). Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day. Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.
InChI:InChI=1/C16H18FN3O3.C3H6O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20;1-2(4)3(5)6/h7-9,18H,2-6H2,1H3,(H,22,23);2,4H,1H3,(H,5,6)
Relevant articles related to Norfloxacin:
|
Article |
Source |
|
Improved method for the synthesis of norfloxacin |
Mokrushina,Kotovskaya,Baskakova,Petrova,Kolmakova,Charushin,Rusinov,Chupakhin , p. 540 - 542 (1996) |
|
Developing ciprofloxacin analogues against plant DNA gyrase: A novel herbicide mode of action |
Wallace, Michael D.,Waraich, Nidda F.,Debowski, Aleksandra W.,Corral, Maxime G.,Maxwell, Anthony,Mylne, Joshua S.,Stubbs, Keith A. supporting information, p. 1869 - 1872 (2018/02/23) |
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