Antioxidant BHT 264
CAS:128-37-0
Purity:99%
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Product Details
The invention discloses a preparation me...
The present invention relates to physica...
Pharmaceutical formulations are provided...
(S)-1,2-Propanediol
(3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol
dapagliflozin (S) propylene glycol hydrate
| Conditions | Yield |
|---|---|
|
(3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol;
With
triethylsilane; boron trifluoride diethyl etherate;
In
acetonitrile;
at 0 - 25 ℃;
Inert atmosphere;
(S)-1,2-Propanediol;
With
water;
In
tert-butyl methyl ether;
|
60% |
dapagliflozin
(S)-1,2-Propanediol
dapagliflozin (S) propylene glycol hydrate
| Conditions | Yield |
|---|---|
|
With
water;
In
tert-butyl methyl ether; cyclohexane;
for 1h;
Product distribution / selectivity;
|
4% |
|
With
water;
In
methanol; Isopropyl acetate; cyclohexane;
at 5 - 20 ℃;
for 1 - 22.1667h;
Product distribution / selectivity;
|
|
|
With
water;
In
methanol; Isopropyl acetate; cyclohexane;
at 5 ℃;
for 1 - 22h;
Product distribution / selectivity;
|
dapagliflozin
(S)-1,2-Propanediol
