Antioxidant BHT 264
CAS:128-37-0
Purity:99%
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The invention relates to a preparation m...
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![1-(4-((4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea](/upload/2026/7/39765dcb-a13b-41c9-9ad0-2740fa01ffab.png)
1-(4-((4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea
tucatinib
| Conditions | Yield |
|---|---|
|
With
p-toluenesulfonyl chloride; sodium hydroxide;
In
tetrahydrofuran;
|
96% |
|
With
p-toluenesulfonyl chloride; sodium hydroxide;
In
tetrahydrofuran;
|
96% |
|
With
p-toluenesulfonyl chloride; sodium hydroxide;
In
tetrahydrofuran;
|
92% |
|
With
p-toluenesulfonyl chloride; sodium hydroxide;
In
tetrahydrofuran;
at 50 - 60 ℃;
for 3h;
|
77% |
|
With
p-toluenesulfonyl chloride; sodium hydroxide;
In
tetrahydrofuran;
|
4,4-dimethyl-2-(methylthio)-4,5-dihydrooxazole trifluoromethanesulfonate
N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)quinazoline-4,6-diamine
tucatinib
| Conditions | Yield |
|---|---|
|
4,4-dimethyl-2-(methylthio)-4,5-dihydrooxazole trifluoromethanesulfonate;
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)quinazoline-4,6-diamine;
In
N,N-dimethyl-formamide;
at 125 ℃;
for 20h;
|
76% |
|
4,4-dimethyl-2-(methylthio)-4,5-dihydrooxazole trifluoromethanesulfonate;
With
caesium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 1h;
N4-(4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylphenyl)quinazoline-4,6-diamine;
In
N,N-dimethyl-formamide;
at 125 ℃;
for 20h;
Reagent/catalyst;
Sealed tube;
|
70% |
1-(4-((4-([1,2,4]triazolo[1,5-α]pyridin-7-yloxy)-3-methylphenyl)amino)quinazolin-6-yl)-3-(1-hydroxy-2-methylpropan-2-yl)thiourea
2-methyl-4-nitrophenol
4-chloro-2-nitropyridine
4-(2-methyl-4-nitrophenoxy)pyridin-2-amine
